A forested valley with autumn foliage, a rocky cliff, and a sunset.

Southern Illinois Hotel Guide - Luxury Hotels in Southern Illinois, Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Luxury Hotels

Tonight
15 Sept - 16 Sept
Tomorrow
16 Sept - 17 Sept
This weekend
18 Sept - 20 Sept
Next weekend
25 Sept - 27 Sept

Our top choices for Southern Illinois luxury hotels

A lobby with a central table, seating area, and a stone pillar with a mirror.
A restaurant with multiple tables, chairs, and a stone fireplace.
A modern hotel lobby with a sectional sofa, armchairs, a coffee table, and abstract wall art.
An outdoor patio with wicker furniture, a stone fire pit, and potted plants.

1. DoubleTree by Hilton Collinsville - St. Louis

DoubleTree by Hilton Collinsville - St. Louis
Eastport
  • Upscale St. Louis hotel offers steakhouse, indoor pool, and 24-hour fitness centre.
€138
includes taxes & fees
15 Oct - 16 Oct
DoubleTree by Hilton Collinsville - St. Louis
An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.
An outdoor patio area with tables and chairs, large windows, and red umbrellas.
A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.
A modern indoor seating area with leather chairs and tables, a central round table, and a staircase leading to an upper level.

2. DoubleTree by Hilton Mt. Vernon

DoubleTree by Hilton Mt. Vernon
Mount Vernon
  • Plush beds and serene pool define luxury at Mt. Vernon retreat where spa awaits after exploration.
€125
includes taxes & fees
1 Oct - 2 Oct
DoubleTree by Hilton Mt. Vernon
A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A hotel reception desk with a modern chandelier, a sign indicating 'SPA' coming soon, and two receptionists at their stations.
A casino interior with slot machines, a large chandelier, and a carpeted floor.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.

3. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
  • Indulge in a luxurious retreat featuring a full-service spa, indoor pool, and casino gaming in the heart of Carterville.
€120
includes taxes & fees
16 Sept - 17 Sept
Walker's Bluff Casino Resort
A cozy living room with a leather sofa, a fireplace, and a chandelier.
A hotel room with a large bed, a desk, a chair, a television, and a painting on the wall.
A two-story house with a porch, a brick foundation, and an American flag.
A living room with a brown leather sofa, a beige armchair, and a matching ottoman. There are two side tables with lamps, a chandelier, and a framed portrait on the wall.

4. Charleston House Bed & Breakfast Inn

Charleston House Bed & Breakfast Inn
Charleston
€113
includes taxes & fees
16 Sept - 17 Sept
Charleston House Bed & Breakfast Inn
A modern hotel lobby with a glass facade, seating area, and a staircase.
A bar area with a bartender, a bar counter with various bottles, and a view of the Gateway Arch.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.
A couple relaxing by a window overlooking a bridge and water.

5. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
€380
includes taxes & fees
16 Sept - 17 Sept
Four Seasons Hotel St Louis
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
A bar area with leather seating, a bar counter, and shelves of bottles.
A lobby with a fireplace, two armchairs, a round table, and a bench.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.

6. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
€555
includes taxes & fees
20 Sept - 21 Sept
The Ritz-Carlton, St. Louis
A modern dining area with multiple tables and chairs, large windows with a city view, and contemporary lighting fixtures.
A rooftop pool area with lounge chairs and a clear view of the city skyline.
A pool table with billiard balls, a sofa, and a ceiling fan in a living room with large windows and a view of the city.
A grand lobby with a high ceiling, ornate chandeliers, and a central seating area with blue upholstered chairs.

7. Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection
Downtown St. Louis
€174
includes taxes & fees
20 Sept - 21 Sept
Hotel Saint Louis, Autograph Collection
A modern outdoor lounge area with seating, a bar, and a view of a cityscape.
A restaurant with tables set for dining, a kitchen in the background, and hanging light fixtures.
The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.
A modern living room with a sofa, coffee table, and bookshelves.

8. Live by Loews - St.Louis

Live by Loews - St.Louis
Downtown St. Louis
€164
includes taxes & fees
27 Sept - 28 Sept
Live by Loews - St.Louis
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
A bar area with multiple seating arrangements, a stage, and a chandelier.
A bakery display case with various pastries and cakes.

9. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
€165
includes taxes & fees
12 Oct - 13 Oct
Ameristar Casino Resort and Spa
A modern lounge with a central fire feature, comfortable seating, and large windows offering a city view.
A bar area with wooden bar stools, a high counter, and a seating area with cushioned sofas and tables.
A rooftop bar with a glass railing, yellow bar stools, and a large umbrella.
A modern bar area with high tables and stools, large windows with city views, and green chandeliers.

10. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
Downtown St. Louis
€160
includes taxes & fees
25 Sept - 26 Sept
Hilton St. Louis at the Ballpark
View all properties

Top Southern Illinois Hotel Reviews

Ramada by Wyndham Effingham

Ramada by Wyndham Effingham

8/10 Good
"Breakfast not even hot tea"
Rhonda 1-night trip
Posted 2 hours ago
Ramada by Wyndham Effingham
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good
"Nice people but it’s been almost 2 weeks since a refund was supposed to reach my account already but still has not. Supposedly released on Sept. 3rd the day we spoke face to face but have yet to receive refund on a room and security deposit. Don’t like that every time I call their number then click option 2 the phone always hangs up no matter the day or time. Please if anyone at the hotel working there can see this review please try to reach out to me so we can resolve this or know what’s going on."
Maximiliano 4-night trip
Posted 6 hours ago
Quality Inn O'Fallon - St. Louis - Shiloh
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"G"
Candy 1-night trip
Posted 10 hours ago
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent
"The amenities where excellent and offered more then other places offer. The staff were kind d and friendly. The rooms where clean, comfortable, and up to what you wa t feom a hotel stay.I would stay there again."
Janet 6-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis Fairview Heights
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

10/10 Excellent
"I enjoyed my stay at Harrahs. The hotel was nice and clean. The staff was friendly and helpful. I ordered room service food from the grill which arrived quickly and tasted fresh. The only thing I was wondering was why The Bridges didn't have room service. I did go to Bridges for breakfast and it tasted fresh and flavorful. I enjoyed the casino with had a good selection of slots, but I would stay there even without gaming. I enjoyed it very much."
Alisa 1-night trip
Posted 3 days ago
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Explore a world of travel with Expedia