Southern Illinois Luxury Hotels, Illinois: Southern Illinois Hotel Guide

A forested valley with autumn foliage, a rocky cliff, and a sunset.

A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Check availability on Southern Illinois Luxury Hotels

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13 Nov - 15 Nov

Our top choices for Southern Illinois luxury hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

United States

Richard

includes taxes & fees

8 Nov - 9 Nov

A hotel with a covered entrance, stone pillars, and a modern design.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

United States

Doug

includes taxes & fees

29 Nov - 30 Nov

A hotel lobby with a reception desk, seating area, and a large screen TV.

3. Comfort Suites Mount Vernon

Mount Vernon

United States

Bruce and Robin

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

United States

Susan

includes taxes & fees

12 Nov - 13 Nov

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

5. Quality Inn Mount Vernon, IL

Mount Vernon

United States

Ryan

includes taxes & fees

29 Nov - 30 Nov

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

6. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

United States

Leslie

includes taxes & fees

9 Nov - 10 Nov

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

7. DoubleTree by Hilton Mt. Vernon

Mount Vernon

United States

Kenneth

includes taxes & fees

7 Nov - 8 Nov

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

8. Best Western Plus Centralia Hotel & Suites

Centralia

United States

Jeremy

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

9. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

United States

Tad

includes taxes & fees

1 Dec - 2 Dec

A cozy living room with a stone fireplace, leather sofas, and a flat-screen TV.

10. Cobblestone Inn & Suites - Altamont

Altamont

United States

Heidi

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a diving board, a changing room, and a tiled floor.

11. Days Inn by Wyndham Mount Vernon

Mount Vernon

United States

Howard

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio area with wicker furniture, a stone pillar, and a glass-enclosed dining area.

12. Holiday Inn Express & Suites Salem by IHG

Salem

United States

John

includes taxes & fees

15 Nov - 16 Nov

A small, clean room with a microwave, a vending machine, and a table with chairs.

13. Rodeway Inn Mount Vernon, IL

Mount Vernon

United States

Karalee

includes taxes & fees

1 Nov - 2 Nov

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

14. Best Western U. S. Inn

Nashville

United States

Steven

includes taxes & fees

5 Nov - 6 Nov

A hotel room with a bed, a desk with a chair, a sofa, and a small table.

15. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

United States

Colleen

includes taxes & fees

1 Dec - 2 Dec

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

16. Super 8 by Wyndham Salem

Salem

United States

Sarah

includes taxes & fees

8 Nov - 9 Nov

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

17. La Quinta Inn & Suites by Wyndham Effingham

Effingham

United States

Steve

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with a fire pit, surrounded by wooden chairs and a view of a sunset over a landscaped garden.

18. Best Western Plus Parkside Inn & Suites

Olney

United States

Lynda

includes taxes & fees

25 Nov - 26 Nov

An outdoor patio area with a fire pit, seating, and a covered section.

19. Home2 Suites By Hilton Effingham

Effingham

United States

Steve

includes taxes & fees

1 Dec - 2 Dec

A hotel with a covered entrance, a sign indicating it is now open, and a sign for the Cobblestone Hotel & Suites.

20. Cobblestone Hotel & Suites - Newton

Newton

United States

Thomas

includes taxes & fees

1 Nov - 2 Nov

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Top Southern Illinois Hotel Reviews

Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

8/10 Good

"friendly staff, comfortable rooms, breakfast a plus."

Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good

"The staff was awesome! The bathroom however had some stains on the shower curtain. It should have been washed . The bed was so very comfortable! We slept great! Thank you… The staff came right to the room when we couldn’t get the tv remote to work. Asked if we needed anything else.."

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