A calm lake surrounded by trees and vegetation.

Southwest Illinois Hotel Guide - Luxury Hotels in Southwest Illinois, Illinois

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Check availability on Southwest Illinois Luxury Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Southwest Illinois luxury hotels

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A hotel reception desk with a modern chandelier, a sign indicating 'SPA' coming soon, and two receptionists at their stations.
A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.

1. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
  • Indulge in a luxurious retreat featuring a full-service spa, indoor pool, and casino gaming in the heart of Carterville.
€124
includes taxes & fees
12 Oct - 13 Oct
Walker's Bluff Casino Resort
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

2. The Riverview

The Riverview
Cape Girardeau
€115
includes taxes & fees
13 Oct - 14 Oct
The Riverview
A cozy lounge area with leather sofas, a fireplace, and a bar counter.
A modern building with a unique, curved roof structure.
A restaurant with a central bar area, seating arrangements, and a fireplace.
An outdoor patio area with a pool, red umbrellas, and seating arrangements.

3. The Cheshire

The Cheshire
Richmond Heights
€157
includes taxes & fees
25 Oct - 26 Oct
The Cheshire
A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.
An outdoor patio with a brick fireplace, wicker furniture, and a dining table set with food and drinks.
A restaurant with multiple dining tables and chairs, a bar area with shelves of bottles, and a large mirror above the bar.
A bar area with a marble counter, bar stools, and a variety of liquor bottles.

4. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
Central West End
  • Indulge in historic elegance at this St. Louis gem featuring 3 restaurants, a spectacular pool area, and luxurious rooms near Forest Park.
€196
includes taxes & fees
1 Nov - 2 Nov
The Royal Sonesta Chase Park Plaza St. Louis
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.

5. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Indulge in artistic luxury at this city centre St. Louis hotel with spa services and indoor pool.
€154
includes taxes & fees
1 Nov - 2 Nov
21C Museum Hotel St Louis
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A bar area with multiple seating arrangements, a stage, and a chandelier.
A bakery display case with various pastries and cakes.
A grand lobby with a central chandelier, multiple levels, and rows of liquor bottles.

6. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
€201
includes taxes & fees
14 Oct - 15 Oct
Ameristar Casino Resort and Spa
A restaurant with round tables and chairs, a bar area, and a patterned ceiling.
A spa bath with a sign indicating a capacity of 8 persons.
An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.
A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.

7. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
€139
includes taxes & fees
1 Nov - 2 Nov
Drury Plaza Hotel St. Louis Brentwood
A wooden treehouse with a glass window, surrounded by dense forest.
A bedroom with a skylight, a bed with pillows, a nightstand, and a wall with a forest mural.
A modern interior with a herringbone-patterned wooden wall above a fireplace, dark tiled lower section, and a window with a view.
A bathroom with a wooden vanity, a round mirror, and three wall-mounted lights.

8. TreeLoft at BaseCamp

TreeLoft at BaseCamp
Perryville
TreeLoft at BaseCamp
A modern hotel lobby with a glass facade, seating area, and a staircase.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.
A couple relaxing by a window overlooking a bridge and water.
A bar area with a bartender, a bar counter with various bottles, and a view of the Gateway Arch.

9. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
€391
includes taxes & fees
11 Oct - 12 Oct
Four Seasons Hotel St Louis
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Top Southwest Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"This was the best hotel I’ve stayed in. The accommodations were outstanding with wonderful people managing the desk! Two young ladies helped us and it was amazing!"
Gina 1-night trip
Posted 11 hours ago
Drury Plaza Hotel Mt. Vernon
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good
"Would stay there again"
Lidia 1-night trip
Posted 12 hours ago
Quality Inn O'Fallon - St. Louis - Shiloh
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent
"Lovely 3 night stay. Was greeted with a warm welcome, invited for happy hour and a dinner if we did not eat yet! Suite was clean, pool and hot tub area were clean as well. If in area again we will definitely book here!!!"
Jason 3-night trip
Posted 12 hours ago
Drury Inn & Suites St. Louis Fairview Heights
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"Of all the hotels I stayed at, these were probably the most comfortable beds I have ever slept in. Rooms for very clean. Pool area was nice. My would maybe suggest a few more options for the breakfast but what they did have was good."
Jennifer 1-night trip
Posted 13 hours ago
Comfort Suites Mount Vernon
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

10/10 Excellent
"Our room was very nice & bed was comfortable Easy free parking & close to highway"
Victor 1-night trip
Posted 3 days ago
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent
"This is an excellent hotel to stay at. Updated, easy parking, staff is very friendly, breakfast is great, will stay at this hotel again."
Lisa 3-night trip
Posted 13 days ago
Country Inn & Suites by Radisson, Marion, IL

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