4 Star Hotels in Southeast Missouri, Missouri
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Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews
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Hotel Theme
- Adventure Sport Hotels in Southeast Missouri
- Business Hotels in Southeast Missouri
- Casino Hotels in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Friendly Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotels with Air Conditioning in Southeast Missouri
- Hotels with Bar in Southeast Missouri
- Hotels with Breakfast in Southeast Missouri
- Hotels with Connecting Rooms in Southeast Missouri
- Hotels with Parking in Southeast Missouri
- Hotels with Pool in Southeast Missouri
- Hotels with Restaurant in Southeast Missouri
- Hotels with Spa in Southeast Missouri
- Hotels with WiFi in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet Friendly Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Wedding Hotels in Southeast Missouri
More accommodation types in Southeast Missouri
- Holiday Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- Caravan Parks in Southeast Missouri
- Lodges in Southeast Missouri
- Aparthotels in Southeast Missouri
- Condo Rentals in Southeast Missouri
- B&B in Southeast Missouri
- Villas in Southeast Missouri
More top Southeast Missouri Hotels
- Pear Tree Inn Cape Girardeau West
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Postcard Cabins St. Francois
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Drury Inn & Suites Sikeston, MO
- Days Inn and Suites by Wyndham Sikeston
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Super 8 by Wyndham Farmington
- Drury Inn & Suites Jackson MO
- Drury Inn & Suites Cape Girardeau
- Tru By Hilton Cape Girardeau
- Drury Inn & Suites Poplar Bluff
- Super 8 by Wyndham Perryville
- Holiday Inn Poplar Bluff by IHG
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