Defiance Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Defiance hotels

Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG
3.5 star property
Bridgeton
8.0 out of 10, Very good, (1,004 reviews)
"Great place to stay "
United States
Taylor
The price is €114
includes taxes & fees
2 Apr - 3 Apr
Crowne Plaza St. Louis Airport by IHG

Embassy Suites by Hilton St. Louis Airport

Embassy Suites by Hilton St. Louis Airport
3.5 star property
Bridgeton
7.6 out of 10, Good, (1,000 reviews)
"The staff was so friendly "
United States
Kathryn
The price is €139
includes taxes & fees
8 Mar - 9 Mar
Embassy Suites by Hilton St. Louis Airport

Comfort Inn St. Louis Airport

Comfort Inn St. Louis Airport
3.0 star property
Bridgeton
8.4 out of 10, Very good, (954 reviews)
"Friendly staff, clean room, comfortable bed "
United States
Judith
The price is €100
includes taxes & fees
15 Mar - 16 Mar
Comfort Inn St. Louis Airport

MainStay Suites St Louis Airport

MainStay Suites St Louis Airport
3.0 star property
Bridgeton
8.2 out of 10, Very good, (308 reviews)
"Great stay and office staff very friendly."
United States
Neil
The price is €105
includes taxes & fees
16 Mar - 17 Mar
MainStay Suites St Louis Airport

Extended Stay America Select Suites - St. Louis - Airport - Central

Extended Stay America Select Suites - St. Louis - Airport - Central
2.5 star property
Bridgeton
7.0 out of 10, Good, (1,004 reviews)
"Clean and respectful staffs "
United States
Dr. Sampson
The price is €88
includes taxes & fees
15 Mar - 16 Mar
Extended Stay America Select Suites - St. Louis - Airport - Central

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1,001 reviews)
"Great staff"
United States
irene
The price is €137
includes taxes & fees
8 Mar - 9 Mar
Hilton St. Louis Frontenac

La Quinta Inn & Suites by Wyndham St. Louis Westport

La Quinta Inn & Suites by Wyndham St. Louis Westport
3.0 star property
Maryland Heights
7.2 out of 10, Good, (1,102 reviews)
"Not too bad of a stay. Staff was nice"
United States
Jasmine
The price is €97
includes taxes & fees
3 Mar - 4 Mar
La Quinta Inn & Suites by Wyndham St. Louis Westport

Red Roof Inn St Louis - Westport/ Maryland Heights

Red Roof Inn St Louis - Westport/ Maryland Heights
2.0 star property
Maryland Heights
5.4 out of 10, (1,003 reviews)
"Pretty spotless for the most part "
United States
David
The price is €59
includes taxes & fees
5 Mar - 6 Mar
Red Roof Inn St Louis - Westport/ Maryland Heights

Courtyard by Marriott St Louis Westport Plaza

Courtyard by Marriott St Louis Westport Plaza
3.0 star property
Maryland Heights
8.8 out of 10, Excellent, (1,002 reviews)
"Great location , hotel"
United States
jennifer
The price is €114
includes taxes & fees
29 Mar - 30 Mar
Courtyard by Marriott St Louis Westport Plaza

Fairfield Inn & Suites St Louis Westport

Fairfield Inn & Suites St Louis Westport
3.0 star property
Maryland Heights
9.2 out of 10, Wonderful, (830 reviews)
"Very clean nice room! Attentive staff and area for breakfast was spotless and had good options for food. "
United States
Jim
The price is €124
includes taxes & fees
8 Mar - 9 Mar
Fairfield Inn & Suites St Louis Westport

Residence Inn St Louis Westport

Residence Inn St Louis Westport
3.0 star property
Maryland Heights
9.2 out of 10, Wonderful, (415 reviews)
"Great room for the price. Breakfast was amazing and the staff is super friendly! "
United States
Jimmy
The price is €161
includes taxes & fees
29 Mar - 30 Mar
Residence Inn St Louis Westport

Studio 6 Extended stay - St Louis, MO - Westport/Craig Road

Studio 6 Extended stay - St Louis, MO - Westport/Craig Road
2.0 star property
Maryland Heights
6.4 out of 10, (813 reviews)
"Clean rooms, nice staff!"
United States
Peter
The price is €70
includes taxes & fees
29 Mar - 30 Mar
Studio 6 Extended stay - St Louis, MO - Westport/Craig Road

Homewood Suites by Hilton St. Louis Westport

Homewood Suites by Hilton St. Louis Westport
3.0 star property
Maryland Heights
8.8 out of 10, Excellent, (466 reviews)
"Very friendly & clean! "
United States
Meagan
The price is €183
includes taxes & fees
6 Mar - 7 Mar
Homewood Suites by Hilton St. Louis Westport

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1,048 reviews)
"This place is always good. Been there +10 times."
United States
Federico Gavuzzo
The price is €86
includes taxes & fees
6 Mar - 7 Mar
Best Western Plus St. Louis West-Westport

Hampton Inn St. Louis/Westport

Hampton Inn St. Louis/Westport
2.5 star property
Maryland Heights
7.8 out of 10, Good, (981 reviews)
"Room was fine, Staff was pleasant, neighbors were loud after midnight"
United States
Leo
The price is €102
includes taxes & fees
29 Mar - 30 Mar
Hampton Inn St. Louis/Westport

Sheraton Westport Plaza Hotel St. Louis

Sheraton Westport Plaza Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very good, (865 reviews)
"Room was clean and it had a great view on 11th floor. I love that there is a little plaza/mall attached to the hotel it’s very nice. Overall it was a great stay and I will be staying her again in the future. "
United States
Kobe
The price is €213
includes taxes & fees
6 Mar - 7 Mar
Sheraton Westport Plaza Hotel St. Louis

Staybridge Suites St Louis - Westport by IHG

Staybridge Suites St Louis - Westport by IHG
3.0 star property
Maryland Heights
8.8 out of 10, Excellent, (608 reviews)
"Breakfast was good I don't think I have ever been disappointed with a stay bridge ."
United States
Jimmy or Falyn
The price is €141
includes taxes & fees
6 Mar - 7 Mar
Staybridge Suites St Louis - Westport by IHG

Extended Stay America Suites St Louis Westport Central

Extended Stay America Suites St Louis Westport Central
2.5 star property
Maryland Heights
7.6 out of 10, Good, (1,001 reviews)
"The room was very clean and comfortable. "
United States
Debra
The price is €90
includes taxes & fees
29 Mar - 30 Mar
Extended Stay America Suites St Louis Westport Central

Courtyard by Marriott St Louis Creve Coeur

Courtyard by Marriott St Louis Creve Coeur
3.0 star property
Creve Coeur
8.8 out of 10, Excellent, (1,002 reviews)
"Spacious and clean room with very comfortable beds! "
United States
Heather
The price is €120
includes taxes & fees
15 Mar - 16 Mar
Courtyard by Marriott St Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur
3.0 star property
Creve Coeur
9.2 out of 10, Wonderful, (1,006 reviews)
"Great clean hotel with free breakfast. "
United States
Jennifer
The price is €126
includes taxes & fees
8 Mar - 9 Mar
Drury Plaza Hotel St. Louis Creve Coeur
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia