Photo by Bill Dillard
Southeast Missouri Hotel Guide - Historic Hotels in Southeast Missouri, Missouri
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Historic Hotels
Our top choices for Southeast Missouri historic hotels
Beautiful Modern Loft In Wine Country!
Beautiful Modern Loft In Wine Country!Ste. Genevieve
10.0 out of 10, Exceptional, (275 reviews)
"It was the perfect spot for a weekend getaway!"
Brittany P.
The price is €160
includes taxes & fees
4 Apr - 5 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing SpaceCape Girardeau
10.0 out of 10, Exceptional, (152 reviews)
"Wonderful location! WonderfulStay"
Alison C.
The price is €215
includes taxes & fees
1 Apr - 2 Apr
The Weber Farm - Enjoy a beautiful 100 acre farm!
The Weber Farm - Enjoy a beautiful 100 acre farm!Frohna
10.0 out of 10, Exceptional, (32 reviews)
"We enjoyed the beautiful countryside. "
Jaymie T.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.Anna
10.0 out of 10, Exceptional, (407 reviews)
"Great location. Cozy cabin. Would stay there again. "
jeffrey s
The price is €176
includes taxes & fees
30 Mar - 31 Mar
Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake AcreDongola
10.0 out of 10, Exceptional, (102 reviews)
"Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location "
carlton h.
The price is €248
includes taxes & fees
31 Mar - 1 Apr
Peter Ray House
Peter Ray HouseMaeystown
10.0 out of 10, Exceptional, (72 reviews)
"The house was wonderful, the town was delightful, and the people were very friendly! We can’t wait for our next trip!"
Deborah
The price is €193
includes taxes & fees
31 Mar - 1 Apr
Chic Minimalist Gem w/ Fenced Backyard + W/D
Chic Minimalist Gem w/ Fenced Backyard + W/DPrinceton Heights
9.8 out of 10, Exceptional, (11 reviews)
"Clean, very comfortable apartment in a great location: easy walk to restaurants, coffee shops, Francis Park. Attractive, quiet, tree-lined neighborhood. Would definitely stay here again!"
Jack S.
The price is €179
includes taxes & fees
1 Apr - 2 Apr
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!The Hill
9.8 out of 10, Exceptional, (172 reviews)
"Easy access and great location. Place was kept very clean. "
Andrew P.
The price is €136
includes taxes & fees
31 Mar - 1 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
Explore a world of travel with Expedia
- Allenville Hotels
- Arcadia Hotels
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bonne Terre Hotels
- Broseley Hotels
- Bunker Hotels
- Caledonia Hotels
- Cape Girardeau Hotels
- Cherryville Hotels
- Clearwater Hotels
- Desloge Hotels
- St. Francois County Hotels
- Hotels with Pool in Dexter
- Dexter Hotels
- Wyndham Hotels in Doe Run
- Hotels near eDen Spa & Salon
- Ellington Hotels
- Eminence Hotels
- Fredericktown Hotels
- Fruitland Hotels
- Gordonville Hotels
- Historic Hotels in Ironton
- Ironton Hotels
- Lesterville Hotels
- Marble Hill Hotels
- Cabin Rentals in Middle Brook
- Hilton Hotels in Middle Brook
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Perryville Hotels
- Poplar Bluff Hotels
- Qulin Hotels
- Sikeston Hotels
- Motel 6 Hotels in Southeast Missouri
- Hotels near Southeast Missouri State University
- B&B in St Mary
- Ste Genevieve Hotels
- Aimbridge Hospitality Hotels in Tiff
- Tiff Hotels
- Hotels near Trail of Tears State Park
- Van Buren Hotels
- Arcadia Holidays
- Visit Bernie
- Visit Bloomsdale
- Visit Bonne Terre
- Cave Spring Park
- Dexter Holidays
- Visit Doniphan
- Eden Spa & Salon
- Visit Fredericktown
- Visit Grandin
- Johnson's Shut-ins State Park
- K Bridge Recreation Area
- Visit Old Appleton
- Visit Ozora
- Visit Park Hills
- Visit Qulin
- Rocky Falls
- Van Buren Holidays
- Visit Van Buren
- Walnut Hollow Lake
- Visit Wappapello
- Washington State Park
- Ace New Zealand Rental Cars in Doe Run
- Ada Rental Cars in New Offenburg
- Addcar rental Rental Cars in Fruitland
- Apex Car Rentals Rental Cars in Southeast Missouri
- Auto Rent Rental Cars in Black
- Car hire Black
- Goldcar Key’n Go Rental Cars in Cherryville
- Island Car Rentals Rental Cars in Ellington
- Ok Mobility Rental Cars in Grandin
- Priceless Car Rental Rental Cars in Black
- Sicily By Car Rental Cars in Delta