Photo by Bill Dillard
Southeast Missouri Hotel Guide - Historic Hotels in Southeast Missouri, Missouri
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Our top choices for Southeast Missouri historic hotels
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4Ste. Genevieve
10.0 out of 10, Exceptional, (18)
"Great historic property!"
Rhonda R.
The price is €181
includes taxes & fees
31 Dec - 1 Jan 2026
Beautiful Modern Loft In Wine Country!
Beautiful Modern Loft In Wine Country!Ste. Genevieve
10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
Elsie H.
The price is €156
includes taxes & fees
19 Jan - 20 Jan 2026
The Weber Farm - Enjoy a beautiful 100 acre farm!
The Weber Farm - Enjoy a beautiful 100 acre farm!Frohna
10.0 out of 10, Exceptional, (32)
"Hosts were great. I just wish they had a second bath or atleast a larger bathroom. "
Dennis H.
The price is €145
includes taxes & fees
1 Jan - 2 Jan 2026
"Little Brick House on Main (1865)”
"Little Brick House on Main (1865)”Ste. Genevieve
10.0 out of 10, Exceptional, (63)
"Great place to stay!"
Lettitia B.
The price is €139
includes taxes & fees
6 Jan - 7 Jan 2026
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing SpaceCape Girardeau
10.0 out of 10, Exceptional, (149)
"Such a great place and location"
Tracy H.
The price is €214
includes taxes & fees
28 Dec - 29 Dec
7.2 out of 10, Good, (332)
"Very clean room. Staff was helpful and courteous. Good value for the price. "
Peggy
The price is €51
includes taxes & fees
28 Dec - 29 Dec
Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake AcreDongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
carlton h.
The price is €247
includes taxes & fees
28 Dec - 29 Dec
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.Anna
10.0 out of 10, Exceptional, (405)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
Tommy
The price is €176
includes taxes & fees
28 Dec - 29 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
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- Allenville Hotels
- Arcadia Hotels
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bonne Terre Hotels
- Broseley Hotels
- Bunker Hotels
- Caledonia Hotels
- Cape Girardeau Hotels
- Cherryville Hotels
- Clearwater Hotels
- Desloge Hotels
- St. Francois County Hotels
- Hotels with Pool in Dexter
- Dexter Hotels
- Wyndham Hotels in Doe Run
- Hotels near eDen Spa & Salon
- Ellington Hotels
- Eminence Hotels
- Fredericktown Hotels
- Fruitland Hotels
- Gordonville Hotels
- Historic Hotels in Ironton
- Ironton Hotels
- Lesterville Hotels
- Marble Hill Hotels
- Cabin Rentals in Middle Brook
- Hilton Hotels in Middle Brook
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Perryville Hotels
- Poplar Bluff Hotels
- Qulin Hotels
- Sikeston Hotels
- Motel 6 Hotels in Southeast Missouri
- Hotels near Southeast Missouri State University
- B&B in St Mary
- Ste Genevieve Hotels
- Aimbridge Hospitality Hotels in Tiff
- Tiff Hotels
- Hotels near Trail of Tears State Park
- Van Buren Hotels
- Arcadia Holidays
- Visit Bernie
- Visit Bloomsdale
- Visit Bonne Terre
- Cave Spring Park
- Dexter Holidays
- Visit Doniphan
- Eden Spa & Salon
- Visit Fredericktown
- Visit Grandin
- Johnson's Shut-ins State Park
- K Bridge Recreation Area
- Visit Old Appleton
- Visit Ozora
- Visit Park Hills
- Visit Qulin
- Rocky Falls
- Van Buren Holidays
- Visit Van Buren
- Walnut Hollow Lake
- Visit Wappapello
- Washington State Park
- Ace New Zealand Rental Cars in Doe Run
- Ada Rental Cars in New Offenburg
- Addcar rental Rental Cars in Fruitland
- Apex Car Rentals Rental Cars in Southeast Missouri
- Auto Rent Rental Cars in Black
- Car hire Black
- Goldcar Key’n Go Rental Cars in Cherryville
- Island Car Rentals Rental Cars in Ellington
- Ok Mobility Rental Cars in Grandin
- Priceless Car Rental Rental Cars in Black
- Sicily By Car Rental Cars in Delta