A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Southeast Missouri Hotel Guide - Business Hotels in Southeast Missouri, Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Business Hotels

Tonight
28 Sept - 29 Sept
Tomorrow
29 Sept - 30 Sept
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Southeast Missouri business-friendly hotels

A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

1. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
€84
includes taxes & fees
30 Sept - 1 Oct
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A building with a red awning labeled "Shepherd Mountain Inn."
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
€118
includes taxes & fees
30 Sept - 1 Oct
Shepherd Mountain Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A hotel room with two beds, a brick wall, and a wooden headboard.

3. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
€78
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A gym with cardio equipment, a bench press, and a squat rack.

4. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
Joseph
€54
includes taxes & fees
25 Oct - 26 Oct
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Pool
Terrace/patio
Exterior

5. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
€86
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
€99
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
An outdoor patio with tables and chairs, a stone wall, and large windows.

7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
€80
includes taxes & fees
1 Oct - 2 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a bed, a sofa, a desk, and a chair.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

8. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
€113
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Farmington by IHG
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

9. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
€105
includes taxes & fees
14 Oct - 15 Oct
Crown Pointe Lodge, BW Signature Collection
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

10. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
€113
includes taxes & fees
30 Sept - 1 Oct
The Riverview
View all properties

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

8/10 Good
"Staff was friendly, especially in the dining area. Breakfast included was good, but limited selection. Central location with easy access and parking."
Raymond 4-night trip
Posted 2 hours ago
Pear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Staff were helpful."
Joseph 1-night trip
Posted 1 day ago
Baymont Inn and Suites by Wyndham Farmington, MO
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 1 day ago
Comfort Inn Festus - St Louis South
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Great experience. Staff was welcoming. Rooms were clean."
yolanda 2-night trip
Posted 1 day ago
Drury Inn & Suites Hayti Caruthersville
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Debbie at the desk was super nice and helpful."
Nancy 1-night trip
Posted 2 days ago
Holiday Inn Poplar Bluff by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

8/10 Good
"Definitely worth it, clean"
Joy 1-night trip
Posted 3 days ago
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 6 days ago
Drury Inn & Suites Poplar Bluff
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 7 days ago
Days Inn and Suites by Wyndham Sikeston

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Rates for business hotels in Southeast Missouri range between €54 and €118 per night. No matter your budget, Expedia is here to help you find the perfect place to get the job done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southeast Missouri?
Southeast Missouri has multiple business-friendly hotels with a total average guest review rating of 8.8. Attending a work-related event in Cape Girardeau? Hampton Inn Cape Girardeau I 55 East is a 2.5-stars stay that comes highly recommended by corporate travellers and includes a dining venue and a terrace. Another excellent choice for a business trip is Drury Plaza Hotel Cape Girardeau Conference Centre. Also in Cape Girardeau, it has a 3-stars rating and amenities such as a swimming pool and a restaurant.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're meeting with new clients or working remotely, these stays come with the services and amenities you need to be productive.
What are the best cheap business-friendly hotels in Southeast Missouri?
When you're on the road for work in Southeast Missouri, Expedia will help you find the ideal business-friendly hotel. Hampton Inn Cape Girardeau I 55 East is a budget pick in Cape Girardeau. A dining venue and a swimming pool are some of its many amenities. Seeking affordable stays in Sikeston? Pear Tree Inn Sikeston is recommended by many corporate travellers. It offers conveniences that make it easy to both work and play, such as a swimming pool and a spa tub. Business-friendly hotels in Southeast Missouri start at just €54 a night. You'll find tons of fabulous and free attractions wherever you're off to in Southeast Missouri. If you're meeting with clients in Cape Girardeau, try to make time in your schedule for Hunter Valley Winery. You can also see the sights without spending a penny in Sikeston. Sikeston Depot Museum is one of the most popular free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southeast Missouri that are also business friendly?
There sure are. Whether you're searching for a stay in Southeast Missouri with a conference room or a quiet space to work alone, con espacio para trabajar Expedia's got you sorted. Drury Plaza Hotel Cape Girardeau Conference Centre in Cape Girardeau is a fantastic choice. This 3-stars business and family-friendly option comes with all the necessary conveniences, like complimentary breakfast and housekeeping services. Pear Tree Inn Cape Girardeau West is another option in Cape Girardeau where corporate travellers can get some work done with the family in tow. Complimentary breakfast and a laundry service are among the many amenities at this 2.5-stars hotel. When you've finished work, it's time to discover Cape Girardeau with the kids. Popular family-friendly attractions include Cape Splash Family Aquatic Centre and Lazy L Safari Park.
Why book your business-friendly hotel in Southeast Missouri with Expedia?
Expedia is here to help you find an ideal business-friendly hotel when work takes you away from home. From meeting rooms and conference spaces to gyms and on-site restaurants, our stays have all the amenities you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Southeast Missouri?
Select the "business friendly" filter, located under the "traveller experience" heading, to find cheap business-friendly hotels in Southeast Missouri. Then fine-tune your search by your per-night budget. Basing yourself outside the city centre is another easy way to save.
What is there to do in Southeast Missouri near my business-friendly hotel?
The most important accessory for your Southeast Missouri work visit is an epic itinerary for your downtime! Isle Casino Cape Girardeau, Show Me Centre and Riverfront Park are among the top sights if you're headed to Cape Girardeau. Sikeston is also home to terrific attractions, such as Sikeston Depot Museum, Central Park and The Book Bug.

Explore a world of travel with Expedia