Cheap flights to Santa Cruz

View €322 flight on Wed, 8 Apr 2026Opens in a new window

Popular airlines to Santa Cruz

  • Avianca

  • LATAM Airlines Group

  • Boliviana De Aviacion

  • Copa

  • United

  • Air Europa

  • Iberia

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 15% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap round-trip flights to Santa Cruz

Prices were available within the past 7 days and start at €322 for one-way flights and €641 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Sat, 16 May - Thu, 18 Jun
MAD
Madrid
VVI
Santa Cruz
€641 Return, found 4 days ago
€641
Return
found 4 days ago
Select avianca flight, departing Sat, 16 May from Madrid to Santa Cruz, returning Thu, 18 Jun, priced at €641 found 4 days ago
avianca
Sun, 17 May - Sat, 13 Jun
MAD
Madrid
VVI
Santa Cruz
€670 Return, found 4 days ago
€670
Return
found 4 days ago
Select avianca flight, departing Sun, 17 May from Madrid to Santa Cruz, returning Sat, 13 Jun, priced at €670 found 4 days ago
avianca
Mon, 20 Apr - Sat, 16 May
MAD
Madrid
VVI
Santa Cruz
€681 Return, found 21 hours ago
€681
Return
found 21 hours ago
Select avianca flight, departing Mon, 20 Apr from Madrid to Santa Cruz, returning Sat, 16 May, priced at €681 found 21 hours ago
avianca
Mon, 1 Jun - Tue, 16 Jun
MAD
Madrid
VVI
Santa Cruz
€696 Return, found 1 day ago
€696
Return
found 1 day ago
Select avianca flight, departing Mon, 1 Jun from Madrid to Santa Cruz, returning Tue, 16 Jun, priced at €696 found 1 day ago
avianca
Mon, 1 Jun - Tue, 16 Jun
MAD
Madrid
VVI
Santa Cruz
€704 Return, found 1 day ago
€704
Return
found 1 day ago
Select avianca flight, departing Mon, 1 Jun from Madrid to Santa Cruz, returning Tue, 16 Jun, priced at €704 found 1 day ago
Air Europa
Sat, 16 May - Sat, 27 Jun
MAD
Madrid
VVI
Santa Cruz
€715 Return, found 1 day ago
€715
Return
found 1 day ago
Select Air Europa flight, departing Sat, 16 May from Madrid to Santa Cruz, returning Sat, 27 Jun, priced at €715 found 1 day ago
Air Europa
Sat, 14 Nov - Sat, 28 Nov
MAD
Madrid
VVI
Santa Cruz
€730 Return, found 1 day ago
€730
Return
found 1 day ago
Select Air Europa flight, departing Sat, 14 Nov from Madrid to Santa Cruz, returning Sat, 28 Nov, priced at €730 found 1 day ago
Boliviana De Aviacion
Sun, 15 Nov - Sat, 28 Nov
MAD
Madrid
VVI
Santa Cruz
€786 Return, found 1 day ago
€786
Return
found 1 day ago
Select Boliviana De Aviacion flight, departing Sun, 15 Nov from Madrid to Santa Cruz, returning Sat, 28 Nov, priced at €786 found 1 day ago
LATAM Airlines Group
Sun, 15 Nov - Tue, 19 Jan
MAD
Madrid
VVI
Santa Cruz
€826 Return, found 2 days ago
€826
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sun, 15 Nov from Madrid to Santa Cruz, returning Tue, 19 Jan, priced at €826 found 2 days ago
KLM
Sun, 22 Mar - Mon, 20 Apr
DUB
Dublin
VVI
Santa Cruz
€908 Return, found 1 day ago
€908
Return
found 1 day ago
Select KLM flight, departing Sun, 22 Mar from Dublin to Santa Cruz, returning Mon, 20 Apr, priced at €908 found 1 day ago

Trending flights to Santa Cruz

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

KLM
Sun, 22 Mar - Mon, 20 Apr
DUB
Dublin
VVI
Santa Cruz
€908 Return, found 1 day ago
€908
Return
found 1 day ago
Select KLM flight, departing Sun, 22 Mar from Dublin to Santa Cruz, returning Mon, 20 Apr, priced at €908 found 1 day ago

Frequently asked questions

How do I find cheap flights to Santa Cruz that have flexible change policies?
At Expedia, we've been channeling our inner acrobat to help you locate the most flexible airfares available. Just tick the "No change fee" box right underneath the "Flexible change policies" subheading to find your perfect flight to Santa Cruz.
Which airlines fly to Santa Cruz?
BoA runs flights into or near Santa Cruz, including 34 that fly into Viru Viru Intl. Airport (VVI) each month. Choose your holiday dates and then book your fare early for an unbeatable deal.
How can I find cheap tickets to Santa Cruz?
A helpful strategy for getting your hands on cheap airfares is to be flexible with your travel dates. Start by searching for your flight to Santa Cruz, then click on the "flexible dates" box to compare prices for nearby days. Want another tip? Book well ahead. To give you an idea of costs, €641 was the best price for a flight to Santa Cruz in the last seven days.
How much is a flight to Santa Cruz?
There were loads of bargain fares up for grabs in the last seven days, with the cost of a round-trip flight to Santa Cruz ranging between €641 and €908. Many lucky holiday makers nabbed one-way flights from Madrid (MAD) for as little as €322.
What are the most popular airports to fly into in Santa Cruz?
A major entryway to Santa Cruz, about 34 flights touch down at Viru Viru Intl. Airport (VVI) each month. Look for a top deal, book your seat and get set to soak up the best of this fantastic region.
How much is a plane ticket to Santa Cruz?
In the last seven days, seats to Santa Cruz ranged between €641 and €908. Prices depend on multiple things, particularly the time of departure, airline, seating class and how early the fare is booked.
What is the best time to go to Santa Cruz?
Head for Santa Cruz during the busiest months of March, August and September. Tourists flock to renowned cities like Montero around this time. If you're fond of hot weather, it's worth noting that the summer season in Santa Cruz starts December 1. Average temperatures range from 21ºC to 32ºC in Montero then.
What months are the cheapest to book a flight to Santa Cruz?
Book your ticket in February for incredible flight deals to Santa Cruz. December is normally the most expensive time to purchase a seat.

Book with confidence

About Santa Cruz

Expedia offers flights to Santa Cruz to meet every traveller's needs. Whatever your flight need - Expedia has the flight for you. So choose from flights to Santa Cruz or destinations around the world and discover how easy it is to make your flight reservations on Expedia.
About Santa Cruz

Explore a world of travel with Expedia

*Available to Expedia members.