A grand church interior with high vaulted ceilings, large columns, and a central altar.

Florence Hotel Guide. Hotels in Santo Spirito, Florence, Italy

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Our top choices for Santo Spirito hotels

1. Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (688 reviews)
"Beautiful, clean, amazing breakfast, really nice staff. 10/10 recommendation"
United States
Jennifer
The price is €180
includes taxes & fees
29 Jul - 30 Jul
Hotel Horto Convento

2. UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Santo Spirito
8.4 out of 10, Very good, (1,000 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
United Kingdom
Glenn
The price is €103
includes taxes & fees
26 Jul - 27 Jul
UNA Hotels Vittoria Firenze

3. Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (230 reviews)
"I had a lovely stay! Staff were helpful"
United States
Alloura
The price is €84
includes taxes & fees
4 Aug - 5 Aug
Foresteria Valdese di Firenze - Casa per Ferie

4. Palazzo Oliveto

Palazzo Oliveto
Santo Spirito
7.6 out of 10, Good, (104 reviews)
"Good location"
France
Leana
The price is €69
includes taxes & fees
14 Aug - 15 Aug
Palazzo Oliveto

5. La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (183 reviews)
"Really nice, handy location"
United Kingdom
Kate
The price is €127
includes taxes & fees
5 Aug - 6 Aug
La Fonderia Firenze

6. La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.2 out of 10, Wonderful, (277 reviews)
"Great location! Staff was amazing!"
United States
Michelle
The price is €131
includes taxes & fees
4 Aug - 5 Aug
La Torre Del Cestello

7. 1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (198 reviews)
"Great place, very clean and as described in the listing. It has a good AC for the summer months and I highly recommend it."
United States
Jose Felipe
The price is €104
includes taxes & fees
2 Aug - 3 Aug
1900 Artevita

8. Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments
Santo Spirito
9.8 out of 10, Exceptional, (151 reviews)
"We had a very nice stay. Claudia was very friendly and service minded The place serves continental breakfast - and is a good idea to supplement it a little bit! Nice and quiet area, where you can walk to most things We can only recommend it Else Marie Hansen May 2026"
Denmark
Else Marie
The price is €135
includes taxes & fees
12 Aug - 13 Aug
Drom Florence Rooms & Apartments

9. Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (200 reviews)
"Staff very good ! Good ! clean room"
United States
Salomon
The price is €86
includes taxes & fees
26 Jul - 27 Jul
Hotel Firenze 2000

10. Casa Santo Nome di Gesù

Casa Santo Nome di Gesù
Santo Spirito
8.8 out of 10, Excellent, (371 reviews)
"The air-conditioning was perfect, it was very quiet there and the room was spotless. The staff was so helpful to me in finding a restaurant and reserving a taxi. Breakfast was excellent and abundant. What a joy to stay there!"
United States
Jacqueline
The price is €144
includes taxes & fees
1 Aug - 2 Aug
Casa Santo Nome di Gesù

11. Appartamenti degli Artisti by Mmega

Appartamenti degli Artisti by Mmega
Santo Spirito
8.4 out of 10, Very good, (40 reviews)
"Great stay! The place was clean, comfortable, and exactly as described. Would definitely stay again"
United States
Diana
The price is €169
includes taxes & fees
16 Aug - 17 Aug
Appartamenti degli Artisti by Mmega

12. Home in Florence

Home in Florence
Santo Spirito
9.0 out of 10, Wonderful, (77 reviews)
"Wonderful stay again here-our second time. Beautifully clean, perfect location and friendly staff-thankyou for another lovely stay!"
United Kingdom
Victoria
The price is €110
includes taxes & fees
19 Jul - 20 Jul
Home in Florence

13. B&B Mia Palace

B&B Mia Palace
Santo Spirito
8.4 out of 10, Very good, (123 reviews)
"Breakfast was excellent and what a lovely host. "
United Kingdom
Wayne
The price is €105
includes taxes & fees
28 Jul - 29 Jul
B&B Mia Palace

14. Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (174 reviews)
"Really beautiful property and wonderful room. Hotel is immaculately clean and we thought the hotel had been renovated to a beautiful finish. We let the hotel know we were staying for our 10 year anniversary, and a bottle of Prosecco was left in our room with a note, which was extremely kind. A great location to stay in, just across the river. Passcode is provided for front door so can come and go as please. Have booked to stay in again in October!"
United Kingdom
Samantha
The price is €222
includes taxes & fees
4 Aug - 5 Aug
Ottantotto Firenze

15. Mamo Florence - Bice & Krizia Apartments

Mamo Florence - Bice & Krizia Apartments
Santo Spirito
8.0 out of 10, Very good, (5 reviews)
"Very nice apartment and great location. The included parking and laundry facilities were the reason we selected the property, and were very happy with everything. Overall a lovely stay. "
United States
Michele
The price is €190
includes taxes & fees
12 Aug - 13 Aug
Mamo Florence - Bice & Krizia Apartments

16. L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B
Santo Spirito
8.6 out of 10, Excellent, (26 reviews)
"Very goord place to stay"
United States
Victor
The price is €117
includes taxes & fees
19 Jul - 20 Jul
L'Antica Porta Boutique B&B

17. Soggiorno Alessandra

Soggiorno Alessandra
Santo Spirito
8.4 out of 10, Very good, (88 reviews)
"Great location. Away from the central crowds but only a few steps from riverside and short walk to central tourist locations and train stn. Host was awesome. We had a great room (quiet) that included some breakfast items and provided access to shared kitchen. We would stay here again and recommend this to others. "
Canada
Kayedon
The price is €128
includes taxes & fees
26 Jul - 27 Jul
Soggiorno Alessandra

18. AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (233 reviews)
"This was our second time visiting Florence, staying at Astra. We loved the beauty of the rooms and surrounding gardens. The staff were very nice and helpful. It's the perfect blend of amenities and self-service for us. We had a B&B-style breakfast and service with 5-star rooms and vibes."
United Kingdom
Gary
The price is €255
includes taxes & fees
28 Jul - 29 Jul
AdAstra Suites

19. Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
9.0 out of 10, Wonderful, (163 reviews)
"Excellent place"
United States
Laura Patricia
The price is €133
includes taxes & fees
29 Jul - 30 Jul
Residenza D'Epoca Al Numero 8

20. Fuori le Mura di San Frediano - Flo Apartments

Fuori le Mura di San Frediano - Flo Apartments
Santo Spirito
Fuori le Mura di San Frediano - Flo Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santo Spirito

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Lobby
Hotel Horto Convento
4.0 star property
9.8
Exceptional
688 reviews
View
Suite
Palazzo Mannaioni Suites
4.0 star property
9.2
Wonderful
1,139 reviews
View
Rooftop terrace
Hotel Palazzo Guadagni
3.0 star property
9.2
Wonderful
211 reviews
View
Daily continental breakfast for a fee
UNA Hotels Vittoria Firenze
4.0 star property
8.4
Very good
1,000 reviews
View
Suite | Room amenity
Torre di Bellosguardo
4.0 star property
9.0
Wonderful
103 reviews
View

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza del Duomo while you're exploring the neighbourhood.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Signoria and Uffizi Gallery are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Find out more about Santo Spirito

Top reasons to visit Santo Spirito

  • Piazza Santo Spirito: This lively square is the heart of the neighbourhood, bustling with local life and creativity.
  • Historic Church of San Spirito: Explore this stunning church, a gem of Renaissance architecture and art.
  • Wine Tours: Experience Tuscany's exquisite wines through delightful local tours.
  • Charming Accommodation: Enjoy a range of unique lodging options, from stylish lofts to welcoming bed & breakfasts.
  • Scenic Strolls: Wander quaint streets and enjoy picturesque views along the nearby Arno River.

Find great hotels near Santo Spirito

Discover the charming accommodation options in Santo Spirito, Florence, where a delightful mix of hotels and bed & breakfasts await. Whether you're seeking a pet-friendly retreat or a stylish loft adorned with antique furniture, you'll find a variety of choices to suit your taste. Enjoy the vibrant atmosphere of the area, with close proximity to iconic sites like Palazzo Ridolfi and the masterpieces of Fra Bartolomeo, ensuring an unforgettable Tuscan getaway.

  • Hotel Spadai: Hotel Spadai is a splendid 4-star hotel with a remarkable guest rating of 9.8 out of 10, located approximately 1.6km from Santo Spirito. This accommodation is ideal for those seeking an adventurous yet romantic city-themed getaway. Guests can indulge in a variety of onsite adventure sports and recreational activities. The hotel also offers enticing romance packages, including winery tours and limited-hour room service for intimate dining experiences. For relaxation, visitors can unwind with spa amenities such as detoxification wraps, massages, and couples' treatment rooms, alongside a full-service spa and Turkish bath. Its central location enhances the overall romantic atmosphere, making it a charming choice for couples.
  • B&B Hotel Firenze Laurus al Duomo: With a guest rating of 9.2 out of 10, B&B Hotel Firenze Laurus al Duomo is a delightful 4-star accommodation situated just 1.4km from Santo Spirito. This property is tailored for city enthusiasts and shopping aficionados, featuring a pet-friendly policy that allows certain pets on-site. The hotel is conveniently located in a bustling shopping district, perfect for those looking to explore Florence’s vibrant retail scene. Amenities such as a waived fee for service animals, along with specific pet policies, ensure a comfortable stay for both travellers and their furry companions.
  • Hotel Albani Firenze: Hotel Albani Firenze is another 4-star option boasting a guest rating of 9.2 out of 10, located around 1.4km from Santo Spirito. This hotel focuses on providing a family-friendly environment, offering various services and amenities to cater to children. Features such as onsite babysitting and in-room childcare options (for a fee) make it an excellent choice for families looking to explore the beautiful city of Florence together. The welcoming atmosphere and family-centric services create a pleasant experience for guests of all ages.

Where to stay near Santo Spirito

Exploring Santo Spirito in Florence offers a delightful blend of culture and charm. This trendy neighbourhood boasts the picturesque Piazza Santo Spirito, a hub of local life and creativity. Immerse yourself in the rich history of the Florentine Renaissance while wandering its quaint streets. Just a stone’s throw away, you'll discover the romantic allure of the Arno River and the serene beauty of nearby attractions, making it the perfect base for a relaxing Tuscan getaway.

  • Arcetri: Nestled approximately 1.6km from Santo Spirito, Arcetri offers a charming village atmosphere that blends culture with outdoor experiences. This area attracts visitors seeking a tranquil escape, especially during peak seasons in April and from June to July. The local highlights include educational venues, shopping areas, and a relaxing spa. Explore the picturesque piazza square, historic places, and notable monuments that showcase the rich heritage of this quaint village, making it a delightful stop for those interested in both leisure and cultural immersion.
  • San Lorenzo: Located about 1.6km from Santo Spirito, San Lorenzo is a vibrant neighbourhood well-known for its cultural and business-oriented experiences. The area is particularly lively from July through September, drawing in crowds eager to explore the bustling public market and other educational venues. Visitors can enjoy the lively atmosphere of piazza squares and historic spots that define this vibrant community. San Lorenzo’s charm lies in its ability to blend traditional Italian culture with modern urban life, providing a unique experience for every traveller.
  • Santa Croce: Situated around 3.2km from Santo Spirito, Santa Croce is a neighbourhood that remains lively throughout the year. With peak visitor numbers in March, April, and October, it offers a rich cultural experience well-suited for families. The area boasts a variety of markets and shopping districts, making it a perfect destination for those looking to indulge in local flavours and crafts. Notable attractions include the picturesque piazza square, historic landmarks, and a vibrant tourist precinct, ensuring that Santa Croce is a must-visit on your Florentine itinerary.

Things to do near Santo Spirito

Shopping

In Santo Spirito, explore local shops and artisan boutiques that showcase unique gifts and souvenirs. Visit the bustling Mercato di Santo Spirito for fresh produce and handmade items, or stroll through charming streets lined with independent stores, offering a delightful shopping experience in the heart of Florence.

Recreation

In Santo Spirito, indulge in rejuvenating treatments at the luxurious Spa at Hotel Brunelleschi, set in a historic building. For a unique experience, visit the tranquil Yoga in Florence studio, where you can participate in calming classes surrounded by the beauty of Tuscany.

Adventure

At Mugello Circuit, located 27.4km from Santo Spirito, thrill-seekers can indulge in exhilarating motor racing experiences. With its vibrant atmosphere, the circuit offers an exciting backdrop for adrenaline-fuelled events, making it a must-visit for motorsport enthusiasts.

Nightlife

Santo Spirito boasts a vibrant nightlife, with lively bars and intimate venues. Enjoy a relaxed evening at the local wine bars, or dance the night away at trendy clubs. The atmosphere is filled with friendly locals and fellow travellers, creating an inviting and memorable experience.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santo Spirito

To save money on your trip to Santo Spirito, consider visiting during the off-peak months of January to February or November for lower accommodation rates. Booking your hotel about a month in advance can secure better deals, and Monday is the cheapest day to stay. Utilise Expedia’s search tool to find budget-friendly options, and consider packages that combine flights and activities for additional savings. Explore the area on foot to save on transport costs, as many attractions are within walking distance.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santo Spirito are January to February and November, where the prices are slightly lower. This is in comparison to May to June and September, where prices are slightly higher.
  • The best time to book a hotel: Book your hotel around Santo Spirito about 1 month out to secure some of the cheapest prices. If you're the spontaneous type, Expedia's last minute deals and discounts are indicated via the green label below the price.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santo Spirito is Monday. The most expensive day to stay around Santo Spirito is Friday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to specify your budget, preferred location, and additional preferences. You can organise your search results to display prices from lowest to highest, ensuring you find the most affordable hotels first. Furthermore, you have the option to refine your selections by hotel type; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can potentially reduce costs by combining your hotel stay in Santo Spirito with your flights and activities through an Expedia package.

Find the best attractions near Santo Spirito

Santo Spirito in Florence, Tuscany, is ideal for culture, city, and outdoor enthusiasts. Visitors can explore notable attractions such as the charming Santo Spirito Square, the historic church of San Spirito, and various palaces. This vibrant area caters to travellers seeking cultural experiences, family activities, and picturesque cityscapes, making it a perfect destination for an enriching holiday.

  • Piazza della Signoria: A vibrant hub of Florentine life, this historic piazza offers a stunning open-air museum experience, featuring remarkable sculptures such as Michelangelo's David replica and the imposing Palazzo Vecchio. The lively atmosphere and nearby cafés invite leisurely exploration.
  • Cathedral of Santa Maria del Fiore: Known for its magnificent dome designed by Brunelleschi, this iconic cathedral showcases exquisite Gothic architecture. Inside, visitors can admire stunning frescoes and intricate details that reflect the rich cultural heritage of Florence.
  • Ponte Vecchio: This historic bridge, adorned with charming jewellery shops, provides picturesque views of the Arno River. Its unique architecture and vibrant atmosphere make it a delightful spot for a leisurely stroll or a memorable photograph.

Best time to go to Santo Spirito

The best time to visit Santo Spirito is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are moderately high and weather is sunny. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January41.4°F (5.2°C)Light RainMostly SunnyModerately LowSlightly Low
February43.0°F (6.1°C)Light RainMostly SunnyModerately LowSlightly Low
March47.8°F (8.8°C)Light RainMostly SunnyAverageAverage
April54.3°F (12.4°C)Light RainMostly SunnyAverageAverage
May60.4°F (15.8°C)Light RainMostly SunnyAverageSlightly High
June69.6°F (20.9°C)Light RainSunnyAverageSlightly High
July75.2°F (24.0°C)No RainSunnyModerately HighAverage
August75.2°F (24.0°C)No RainSunnyModerately HighAverage
September67.3°F (19.6°C)Light RainMostly SunnyModerately HighSlightly High
October58.8°F (14.9°C)Light RainMostly SunnyAverageAverage
November50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly Low
December43.5°F (6.4°C)Light RainMostly SunnyModerately LowAverage

The nearest major airports for your trip to Santo Spirito

Travelling to Santo Spirito in Florence is convenient with three major airports nearby. Florence Airport (FLR-Peretola) is only 4.8km away, with luxurious options like the Villa Tolomei Hotel & Resort and Rocco Forte Hotel Savoy nearby. Pisa Airport (PSA-Galileo Galilei) is located 67.6km from Santo Spirito, with top hotels such as Toscana Charme Resort and Grand Hotel Bonanno offering shuttle services. Bologna Airport (BLQ-Guglielmo Marconi) is 85.3km distant, with the Starhotels Excelsior and I Portici Hotel providing transportation options. Each airport offers easy access to Santo Spirito, ensuring a seamless travel experience.

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Piazza Santo Spirito and Santo Spirito Basilica as part of your Santo Spirito travel plans.
What's a favourite place to stay in Santo Spirito?
Based on our traveller data, Hotel Horto Convento is one of the top choices for your stay in Santo Spirito. This hotel is a short 14-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and a bar. Other good options for your stay in the neighbourhood include La Torre Del Cestello and UNA Hotels Vittoria Firenze.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 514 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Piazza Santo Spirito and Santo Spirito Basilica are some other places worth a visit. Favourite places to visit in the surrounding area include Piazza di Santa Maria Novella, Uffizi Gallery and Piazza della Signoria. When you're sightseeing in Florence, Cathedral of Santa Maria del Fiore and Piazza del Duomo are also worth a stop.

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