Otay Mesa Hotel Guide - LGBT-Friendly Hotels in Otay Mesa, San Diego

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Check availability on Otay Mesa LGBT-Friendly Hotels

Our top choices for Otay Mesa LGBT-friendly hotels

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Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1560)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is €115
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very good, (3181)
"Great stay! "
United States
Melissa
The price is €123
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton San Diego Resort
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1005)
"Good value Nice place to stay "
United States
John
The price is €91
includes taxes & fees
21 Dec - 22 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1864)
"Enjoyed my stay"
United States
Brandon
The price is €140
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1633)
"Nice rooms. Great food at all restaurants "
United States
Steve
Sycuan Casino Resort
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is €113
includes taxes & fees
16 Dec - 17 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1572)
"Loved our stay "
United States
Jeremy
The price is €171
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina
Standard Room, 1 King Bed, Non Smoking, Bay View
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (733)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is €102
includes taxes & fees
28 Dec - 29 Dec
The DEXTRO Little Italy, BW Premier Collection
Reception
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3571)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is €73
includes taxes & fees
17 Dec - 18 Dec
Kings Inn San Diego
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1282)
"Room was clean,buffet bkfast was good,staff were friendly & helpful!"
United States
Barry
The price is €92
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

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Frequently asked questions

How do I find gay-friendly accommodation in Otay Mesa?
Consider this your open invitation to pack your bags and find LGBTQ-friendly hotels in Otay Mesa on Expedia. People like Otay Mesa for its shopping and restaurants.
What is the top LGBTQ-friendly hotel in Otay Mesa?
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi.
What should I do while I'm visiting Otay Mesa?
During your trip, get out and enjoy everything Otay Mesa has to offer. You and your travelling companions may want to visit San Diego Zoo, San Ysidro Border Crossing and Petco Park. While you're here, capture some great memories of your trip with a stop at Port of San Diego.
What is a gay-friendly hotel in Otay Mesa?
LGBTQ-friendly hotels, also known as gay-friendly hotels, welcome all travellers who identify as LGBTQIA+. We have worked with the International Gay and Lesbian Travel Association (IGLTA) to compile a selection of gay-friendly hotels worldwide. In Otay Mesa, hotels affiliated with IGLTA operate in a spirit of inclusiveness, prioritising a diverse environment in which guests are welcomed, respected and not obliged to declare or hide their sexual orientation.
What can I expect from a gay-friendly hotel in Otay Mesa?
Stay at a gay-friendly hotel in Otay Mesa and you won't have to hide or your sexuality or your gender identity when you check in. Some of Expedia's LGBTQ-friendly hotels go the extra mile and offer concierge services that provide information about nearby LGBTQ restaurants and local events.