Southeast Missouri Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Property class

Top 10 trending Southeast Missouri hotels

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (369)
"Great location and clean room. Plenty of food and shopping nearby."
The price is €105
includes taxes & fees
24 Aug - 25 Aug
Hampton Inn Sikeston

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (784)
"Excellent choice for a stopping point for group of friends traveling through poplar bluff."
The price is €97
includes taxes & fees
17 Aug - 18 Aug
Fairfield Inn & Suites by Marriott Poplar Bluff

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (733)
"Great place to stay convenient walking to multiple restaurants"
The price is €107
includes taxes & fees
10 Aug - 11 Aug
Hampton Inn Cape Girardeau I 55 East

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (660)
"Valid to stay at "
The price is €116
includes taxes & fees
10 Aug - 11 Aug
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great stay!"
The price is €92
includes taxes & fees
10 Aug - 11 Aug
Drury Inn & Suites Hayti Caruthersville

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (23)
"Had a wonderful time"
The price is €115
includes taxes & fees
4 Aug - 5 Aug
Postcard Cabins St. Francois

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Will stay again"
The price is €89
includes taxes & fees
17 Aug - 18 Aug
Drury Inn & Suites Sikeston, MO

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (369)
"A very cool destination!"
The price is €103
includes taxes & fees
4 Aug - 5 Aug
The Riverview

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1002)
"We enjoyed the quick check in and how quiet the property was. "
The price is €68
includes taxes & fees
4 Aug - 5 Aug
Pear Tree Inn Cape Girardeau West

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (288)
"Wonderful small town motel in a beautiful & quiet location."
Shepherd Mountain Inn

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (396)
"Great stay!"
The price is €84
includes taxes & fees
4 Aug - 5 Aug
The Farmstead Hotel

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (748)
"Excellent property, great location. "
The price is €94
includes taxes & fees
17 Aug - 18 Aug
Hampton Inn Poplar Bluff

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (493)
"Super nice staff. Our room smelled so nice and clean. Breakfast was very good too! "
The price is €109
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1006)
"Great place to stay. "
The price is €96
includes taxes & fees
10 Aug - 11 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1006)
"Great place to stay with kids "
The price is €79
includes taxes & fees
10 Aug - 11 Aug
Pear Tree Inn Sikeston

Hampton Inn Farmington

2.5 star property
8.8 out of 10, Excellent, (496)
"Very clean"
The price is €136
includes taxes & fees
24 Aug - 25 Aug
Hampton Inn Farmington

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property
8.0 out of 10, Very good, (827)
"I was very pleased with our stay here. "
The price is €107
includes taxes & fees
31 Aug - 1 Sept
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Century Casino & Hotel Caruthersville

2.0 star property
8.4 out of 10, Very good, (48)
"First time staying, very great staff and pretty Hotel, will return!"
The price is €119
includes taxes & fees
4 Aug - 5 Aug
Century Casino & Hotel Caruthersville

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (49)
"Great overall stay"
The price is €91
includes taxes & fees
10 Aug - 11 Aug
Tru By Hilton Cape Girardeau

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (434)
"Very clean and upscale hotel."
The price is €122
includes taxes & fees
17 Aug - 18 Aug
Courtyard by Marriott Cape Girardeau Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Showing deals for:15 Aug - 17 Aug
Save an average of 15% on thousands of hotels when you're signed in

Near an Attraction

Southeast Missouri State University

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

National Shrine of Our Lady of the Miraculous Medal

National Shrine of Our Lady of the Miraculous Medal

Find out about the history of Perryville with a stop at National Shrine of Our Lady of the Miraculous Medal. Take in the festivals while you're in the area.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews